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Pol J Cosmetol 2010, 13(3): 203-213pl,en  The effect of one-year storage on rheological parameters and pharmaceutical availability of morphine hydrochloride from model ointments with an extract of marigoldGrażyna Samczewska Zakład Farmacji Aptecznej, Katedra Farmacji Stosowanej, Uniwersytet Medyczny w Łodzi Summary Introduction. Striving to obtain analgesic and healing wounds activity, ointments with morphine hydrochloride (MH) and oil (paraffin) extract of marigol (ME)d florescence were produced according to own prescription. Aim. The aim was to determine the effect of one-year storage at 277 K on rheological parameters (perspiration number, extensibitlity, yield stress, thixotrophy) of model vehicles and ointments and on pharmaceutical availability of morphine hydrochloride from ointments not containing and containing extract of marigold. Material and methods. Samples of model vehicles and ointments were closed in aluminium tubes and stored for a year in a refrigerator at 277 K. After one-year storage their pH was determined by potentiometric method, their extensibility by extensiometric method, viscosity parameters were determined by digital cone-plate rheometer and pharmaceutical availability of morphine hydrochloride by spectrophotometric method. The obtained results of tests were compared to the results obtained a year before for fresh vehicles and ointments. Results. After one-year storage pH of ointment containing morphine hydrochloride decreased slightly, perspiration numbers decreased clearly in ointments with morphine hydrochloride and extract of marigold, extensibility and thixotrophy of all tested vehicles and ointments increased, yield stress of vehicles decreased, whereas of ointments with morphine hydrochloride and together with extract of marigold increased, pharmaceutical availability of morphine hydrocholoride increased but to significantly higher degree from ointments containing extract of marigold. Conclusions. Several times increase of the dynamics of morphine hydrochloride release from the stored for one year ointments suggests morphine decomposition. Further appropriately directed studies are needed to solve this problem. Key words: ointments, morphine hydrochloride, oil extract of marigold, viscosity parameters, pharmaceutical availability |