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Copyright @ Pol J Cosmetol
Pol J Cosmetol 2020, 23(4): 249-254pl  Bioavailabilty of selected amino acidsMonika Grzybowska 1,2/, Jacek Arct 3/, Magdalena Krulikowska 4/ 1/ Monat Global Poland 2/ Wyższa Szkoła Zawodowa Kosmetyki i Pielęgnacji Zdrowia w Warszawie 3/ Fundacja dr. Seidla w Warszawie 4/ Henkel Polska Summary Background. One method of improving the amino acids bioavailability is to take advantage of the ion pairs formation with a lipophilic counter-ion. The process of formation and permeation of lipophilic ion pairs can be affected by the emulsion type and composition. Aim. Aim of the present study was to explore impact of the emulsion composition and type on amino acids permeation. Method. The transport of two amino acids: tyrosine and glutamine, from two type of emulsion: the water-in-oil and oil-in-water emulsions was analyzed, using Franz´s chamber. Results and conclusion. Present study shows that the emulsion composition affects the formation of ion pairs and their penetration through the lipid membrane. It was found that the best results in the transport of amino acids in the presence of a liphophilic counter-ion can be achieved by using an oil-in-water emulsion of low viscosity. Key words: amino acids, ion pairs, skin penetration, transepidermal transport, lipid membrane, emulsion |