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Pol J Cosmetol 2020, 23(4): 199-208pl  Methods of assessing bioavailability of active substances in cosmetics. Part I. In vivo methodsJacek Arct 1/, Adam Eysymont 2/ 1/ Fundacja dr Seidla w Warszawie 2/ Wydział Chemiczny, Politechnika Warszawska Summary Today, more and more attention is devoted to the issue of bioavailability of cosmetically active substances. This issue was the forefront of research already in the middle of the last century. The first methods of determining radioactive metabolites in the urine were then developed. Later, these methods were developed, experiments on animals were banned, it turned out that the absorption of the active compound largely depends on the time, frequency and site of application. Currently, with the development of this technique, it has become common to use spectroscopic methods in in vivo research that allow for non-invasive determination of the presence of substances in the different layers of the skin. The most useful method has been the method of laser confocal spectrometry, which, despite limits in quantitative measurements and high costs of the apparatus, has become more widespread and more and more popular in. determination of in vivo bioavailability of cosmetically active substances. Key words: bioavailability, in vivo |