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Copyright @ Pol J Cosmetol
Pol J Cosmetol 2018, 21(4): 314-317pl  Effect of estrogens on the course of melanomaAlicja Sobek, Karol Lorenc, Urszula Fałkowska, Julita Poleszak, Halina Piecewicz-Szczęsna Katedra i Zakład Epidemiologii i Metodologii Badań Klinicznych, Uniwersytet Medyczny w Lublinie Summary Melanoma is a malignant skin cancer. It develops from cells producing pigments, melanocytes. The study presents of the influence of estrogens affecting the milder course of melanoma. The most important study seems to be a study conducted by scientists from the University of Pennsylvania, which shows a milder development of melanoma in mice reproducing a higher level of estrogen, compared with non-pregnant individuals. Another study showed that melanomas containing estrogen receptors were significantly more prevalent in pregnant women with less invasive cancer. During the next study, the systemically delivered agonist of the estrogen receptor coupled to the protein G cooperated with the blockade of the control point in mice with melanoma, easing the course of the disease. Higher estrogen levels contribute to the inhibition of proliferation and increase the degree of melanocyte differentiation, resulting in a milder course of the disease. Key words: melanoma, estrogen, estrogen receptors |