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Copyright @ Pol J Cosmetol
Pol J Cosmetol 2018, 21(3): 253-259pl  Formulation and evaluation of application properties of oleogels containing tea tree oilMagdalena Wróblewska 1/, Ilona Darasz 2/, Katarzyna Winnicka 1/ 1/ Zakład Farmacji Stosowanej, Uniwersytet Medyczny w Białymstoku 2/ studentka, kierunek Kosmetologia, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej, Uniwersytet Medyczny w Białymstoku Summary Introduction. Oleogels are defined as semisolid preparations obtained by gelation of lipophilic liquids with the use of suitable substances forming network structure. They combine the advantages of ointments prepared using traditional basis and oils. Oleogels possess favorable rheological properties, ensure better solubility of hydrophobic compounds, and due to their lipophilic nature, they may provide better penetration of active substances through the stratum corneum. Aim. The purpose of the study was to develop and characterize oleogel formulations as topical drug delivery systems for tea tree oil. The influence of the oil type and the impact of tea tree oil addition on rheological and mechanical characteristics of oleogels as well as their bioadhesive properties were investigated. Material and methods. Oleogels were prepared using different types of oils and colloidal silica as a cross-linking agent. Prepared formulations were subjected to visual analysis, and rheological and mechanical properties such as hardness, cohesiveness, adhesiveness were estimated. An ex vivo adhesion study on the hairless mice skin model as adhesive layer was also carried out. Results and conclusions. The obtained oleogels were non-Newtonian systems, showing a shear-thinning behavior and thixotropic properties. The addition of tea tree oil caused an increase in the viscosity, hardness, cohesiveness and adhesiveness of oleogels and the highest values were observed in the case of oleogel with paraffin oil. It was also found that tea tree oil adversely affected the thixotropic properties of oleogel with castor oil. All preparations possessed bioadhesive properties, and the addition of tea tree oil significantly increased the adhesion of oleogels based on paraffin and castor oil. Designed oleogels with linseed oil and olive oil present promising potential as topical vehicles for tea tree essential oil. Key words: oleogels, tea tree oil, viscosity, textural properties, bioadhesion |