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Copyright @ Pol J Cosmetol
Pol J Cosmetol 2015, 18(1): 51-54pl  Artificial skin - expectation of medicine and cosmetologyKarolina B. Kostecka, Bożena Popłwska, Anna Bielawska Samodzielna Pracownia Biotechnologii Uniwersytetu Medycznego w Białymstoku Summary Human skin is a complex and multi-creation of outstanding regenerative abilities. It is constructed of three layers with a complex structure, with a protective function, thermoregulatory, metabolic, and perceptual. The need for skin grafts due to burns has forced scientists to create many of its substitutes. Integra has gained the greatest popularity, which is biocompatible matrix for the regeneration of the dermis. It is composed of collagen surrounded by chondroitin sulfate and silicone. A number of possibilities in the field of tissue engineering could create a substitute for the skin, which in addition to the blood vessels also includes the lymphatic vessels. Their presence increases the chances of graft acceptance by initiating the process of eating soon after and maintaining tissue fluid balance. French researchers created an artificial skin from human embryonic stem cells by placing them in a special medium containing bone morphogenetic protein and ascorbic acid. Use the scientists induced pluripotent stem cells led to the creation of three-dimensional skin equivalents composed of mature keratinocytes and fibroblasts efficiently producing collagen type VII. The newly created artificial skin model to the greatest extent reproduces the natural permeability barrier of the epidermis, which allows for the testing of new drugs and cosmetics replacing animal models. Achievements in the field of biomedical nanotechnology have allowed the creation of artificial skin receiving the stimulus of touch, temperature and humidity changes through the use of a flexible sensor. Key words: artificial skin, graft, Integra, stem cells, biotechnology |