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Copyright @ Pol J Cosmetol
Pol J Cosmetol 2014, 17(3): 250-256pl  Evaluation of in vivo anti-inflammatory properties of ethanolic extracts from Cucurbita pepo and Linum usitatissimum seedcakesAnna Ratz-Łyko 1/, Jacek Arct 1/, Katarzyna Pytkowska 1/, Monika Kotłowska 2/ 1/ Zakład Chemii Kosmetycznej, Wydział Kosmetologii, Wyższa Szkoła Zawodowa Kosmetyki i Pielęgnacji Zdrowia w Warszawie 2/ Wydział Biotechnologii, Politechnika Warszawska Summary Background. The seedcakes are a rich source of natural bioactive substances: antioxidants, protein and carbohydrates. Thus, may scavenging free radicals and affect on the stratum corneum hydration and epidermal barrier function. Aim. The aim of the present study was to evaluate the in vivo anti-inflammatory properties of oil-in-water emulsions cream with the Cucurbita pepo and Linum usitatissimum seedcake ethanolic extracts. Material and Methods. The in vivo anti-inflammatory properties were evaluated using the methyl nicotinate model of micro-inflammation in human skin measured by chromameter and tewameter. Study was conducted on a group of 10 volunteers after application of oil-in-water emulsions cream with the Cucurbita pepo and Linum usitatissimum seedcake extracts. Results. In in vivo tests the emulsions with Cucurbita pepo and Linum usitatissimum seedcake extracts showed a significant effect on the reduction of erythema and improvement of the state of the epidermal barrier function. The best results were observed after 4 weeks application of the emulsion with Linum usitatissimum seedcake extracts. Conclusions. The study showed that Comparative tests conducted by corneometer and tewameter showed that Cucurbita pepo and Linum usitatissimum seedcake extracts have potential application in moisturizing and protective cosmetics especially designed for sensitive and dry skin. Key words: seedcake extracts, Cucurbita pepo, Linum usitatissimum, methyl nicotinate model of micro-inflammation in human skin, anti-inflammatory activity, epidermal barrier function |