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Pol J Cosmetol 2014, 17(3): 238-243pl  Oxyethylenation products of lard triglycerides in topical semi-solid skin-whitening preparationsMagdalena Piechota-Urbańska, Justyna Tęczar, Justyna Kołodziejska, Małgorzata Godlewska, Aneta Berner-Strzelczyk Katedra Farmacji Stosowanej, Uniwersytet Medyczny w Łodzi Summary Introduction. The presence of appropriately selected promoter of transdermal diffusion in a dermatological preparation may have a positive impact on its therapeutic effectiveness. Good effects of the promoters are observed when they demonstrate amphiphilic properties. Such promoters (e.g. surfactants) act on intracellular proteins and on intercellular lipids. Aim. The aim of the study was to produce topical semi-solid preparations containing arbutin and surfactants - the oxyethylenation products of triglycerides derived from pork lard, to test their pH, rheological properties and also the rate of arbutin release from the formulations produced without and with the surfactant. Material and methods. There were tested seven formulations of fixed content of arbutin and fixed content of the oxyethylenation products of triglycerides derived from pork lard. The preparations were made on the base of lipophilic vehicle emulsifying water. Two types of surfactants were used for the investigations: Curtoil and Frisol 50i, with different content of oxyethylenated segments (from nTE=5 to nTE=40). Potentiometric method was used to measure pH of the produced ointments. Viscosity parameters were determined using cone-plate digital rheometer. The rate of arbutin release through a semipermeable membrane to the acceptor fluid was tested in vitro. Spectrophotometric method was used to determine the quantity of the released arbutin. Results. The obtained results indicate that the kind of the applied surfactant has a significant effect on rheological parameters and on the process of arbutin release from formulations. Formulations with surfactants demonstrated high pharmaceutical availability of therapeutic substance at low viscosity and high extensibility. Conclusions. Application of the oxyethylenation derivatives of pork lard triglycerides in the model vehicles with arbutin contributed to the increase of the process of arbutin pharmaceutical availability. Key words: arbutin, oxyethylenation products of lard triglycerides, pharmaceutical availability |