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Pol J Cosmetol 2011, 14(3): 185-189pl  In vitro research of enhancing properties of cis-ricinoleic acidDanuta Partyka, Andrzej M. Winnicki, Jerzy Krysiński Katedra Technologii Postaci Leku, Collegium Medicum im. L. Rydygiera w Bydgoszczy Uniwersytet Mikołaja Kopernika w Toruniu Summary Introduction. Cis-oleic acid is known and used an enhancer. Castor oil, which contains a cis-ricinoleic acid, is applied in a number of cosmetic formulations. Aim. The aim of the study was evaluation of enhancing properties of cis-ricinoleic acid in comparison to cis-oleic acid. Material and methods. Hydrogels with progesterone (model substance) were applied to the researches, based on the hydroxypropylmethylcellulose, containing 1% and 5% enhancers. Used artificial lipid membranes, were made on the basis of dodecanol and collodion. Quantifications of progesterone were carried out spectrophotmetrically. N-octanol/water partition coefficient and solubility of progesterone were determined in the presence of enhancers. Results. The total amount of progesterone absorbed in the membranes in presence of 1% ricinoleic acid was 58,67±7,50%, 1% oleic acid - 60,83±5,72, 5% ricinoleic acid - 92,31±4,19%, 5% oleic acid - 92,99±5,32%, while the gel without enhancer - 40,71±7,08%. Conclusions. Cis-ricinoleic acid demonstrates similar effect to promote penetration of progesterone into artificial lipid membranes such as cis-oleic acid in both concentrations (1% and 5%). Key words: cis-ricinoleic acid, cis-oleic acid, progesterone, enhancer, artificial lipid membranes |