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Pol J Cosmetol 2011, 14(2): 107-114pl,en  Aloe skin-whitening creamsTeresa Bujak, Marian M. Zgoda, Kazimiera H. Bodek Katedra Farmacji Stosowanej, Uniwersytet Medyczny w Łodzi Summary Aloe (Aloe Arborescens Mill.) - a therapeutic phenomenon among plants - demonstrates multidirectional therapeutic activity conditioned by diverse chemical composition. Aloe extract manifests antibacterial, anti-inflammatory, regenerating and light-protective properties. Aloesin and one of its derivatives - 2"-O-feruloylaloesin isolated from aloe demonstrated effective inhibition of tyrosinase. Aloesin affects the process of melanogenesis (tyrosinase inhibitor). It has skin-lightening activity in skin pigmentation disorders. Aim. To determine pharmaceutical availability of aloenin from freshly produced creams (ex tempore) containing a dry extract of fresh aloe leaves (Aloe Arborescens Mill.). The effect of the vehicle components used in creams on aloenin release from the tested model creams was also estimated. Material and methods. A technology of model aloe skin-whitening creams has been worked out. An analysis of aloenin pharmaceutical availability was performed in the tested creams with a static method based on the dialysis (mass exchange on phase boundary) of an active substance through a selectively permeable Tomofan-type membrane in Mutimer apparatus. In chemical quantitative analysis a direct spectrophotometric method was used to define active substances converted to aloenin. The pharmaceutical availability of the tested creams was determined with biopharmaceutical parameters i.e. constants of release (k) and half-time of release (t50%). Results. The content of aloenin in the analysed material allows to include this compound to dominating ones in the chemical composition of Aloe Arborescens plants grown in greenhouses of Herbal Works "Phytopharm" S.A. in Klęka. On the basis of aloenin release from aloe creams, the usefulness of the proposed vehicles applied in model creams was also tested. Conclusions. The selected Tomofan dialysis membrane gave comparable results in the determinations of pharmaceutical availability and it is very useful in the testing of pharmaceutical availability of aloenin from the investigated creams. The vehicle components affected aloenin release from the tested creams. Key words: Aloe, Aloe arborescens, aloe creams, skin-whitening creams, pharmaceutical availability, aloenin |