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Copyright @ Pol J Cosmetol
Pol J Cosmetol 2009, 12(2): 146-153pl,en  Aloe creams for atopic skinTeresa Bujak, Marian M. Zgoda Katedra Farmacji Stosowanej, Uniwersytet Medyczny w Łodzi Summary Aloe - therapeutic phenomenon among plants - demonstrates multidirectional therapeutic activity conditioned by diverse chemical composition. Aloe extract has antibacterial, anti-inflammatory, regenerating and light-protective properties. Basing on aloe extract from dry leaves, there has been worked out a technology of a few aloe creams taking into account their enrichment with other oiling and moisturizing components to regenerate and nourish atopic skin. Aim. The aim of the study was to determine pharmaceutical availability of aloenin in freshly produced creams containing dry extract from fresh Aloe Arborescens Mill. leaves. The effect was also estimated of the vehicle components used in creams on aloenin release from the tested model creams. Material and Methods. A technology of a few aloe creams for dry atopic skin has been worked out. An analysis of aloenin pharmaceutical availability was performed in the tested creams with a static method based on the dialysis of an active substance through semipermeable Tomophan membrane in Mutimer apparatus. Direct spectrophotometric method was used in chemical analysis to define active substances converted to aloenin. Pharmaceutical availability of the tested creams was determined with biopharmaceutical parameters i.e. constant of release (k) and half time of release (t50%) Results. The results of the tests of aloenin content in the analyzed material enable to include this compound to a group of compounds dominating in the chemical composition of Aloe Arborescens plants grown in greenhouses of Herbal Works "Phytopharm"S.A. in Klęka. Furthermore, on the basis of aloenin release from aloe creams, the usefulness of the suggested vehicles was investigated. Conclusions. The selected Tomophan dialysis membrane gave comparable results in the determinations of pharmaceutical availability and it is very useful in the testing of pharmaceutical availability of aloenin from the investigated creams. The vehicle components affected aloenin release from the tested creams. Introduction of water (moisturizing) and oiling protect skin by strengthening the damaged lipid coat, closing microfissures and eliminating skin cracks. Key words: Aloe, Aloe arborescens, aloe creams, aloe creams for atopic skin, pharmaceutical accessibility, aloenin |