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Pol J Cosmetol 2009, 12(2): 105-116pl,en  Estrogens and the skin biology. Part IIKatarzyna Adamczyk, Magdalena Jurzak Zakład Kosmetologii Śląskiego Uniwersytetu Medycznego w Katowicach Summary The expression analysis of estrogen receptor in human skin and symptoms caused by estrogens deficiency revealed that estrogen take a part in many biological action in human skin. Estrogen receptors are present in: epidermis cells, dermis cells, hair follicles, sweat and sebum glands, skin blood vessels and skin immune system cells. Estrogens regulate process of the epidermis keratinization, melanogenesis, hair cycling and sebum synthesis. They play a role in wound healing process and in autoimmune diseases course. Significant estrogens deficiency, the effect of the menopause is one of major cause of skin aging. In perimenopausal women, the skin gets dry, with weaken resilience, elasticity and thickness. The integrity of the skin and its role in our body protection against harmful influence of the outside environment factors decreases. Estrogens deficiency also impairs wound healing process. Skin symptoms caused by estrogens deficiency can be alleviated by hormone replacement therapy (HRT), selective estrogen receptor modulators (SERMs) and phytoestrogens. Key words: estrogens, skin, HRT, SERM, phytoestrogens |