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Pol J Cosmetol 2008, 11(2): 148-161pl,en  Pharmaceutical availability of ketoprofen from hydrogel vehicles in the presence of dry plant extractsMagdalena Piechota-Urbańska, Aneta Berner-Strzelczyk Katedra Farmacji Stosowanej, Uniwersytet Medyczny w Łodzi Summary Introduction. An attempt was made to introduce into a hydrogel vehiculum a nonsteroidal anti-inflammatory drug (ketoprofen) together with dry standardized plant extracts to obtain synergy in the area of analgesic and anti-inflammatory activity. Material and method. Model hydrogel preparations were produced on the carbopol, CMC-Na and chitosan base and they contained dry standardized plant extracts and ketoprofen. Extensometric method was used to test extensibility of the preparations, viscosity parameters were determined with cone-plate digital rheometer, potentiometric method was applied to measure pH of the produced hydrogels. The test for therapeutic agents pharmaceutical availability was performed by membrane method using spectrophotometric method for the evaluation of released therapeutic substance. Results. Viscosity tests demonstrated that the suggested formulations are viscoelastic systems having yield stress. The formulations produced on carbopol base have the highest values of the areas under release curves of therapeutic agents from dry plant extracts despite high viscosity values. Introduction of dry standardized plant extracts into formulations with ketoprofen does not affect significantly the pharmaceutical availability of ketoprofen. The process of ketoprofen release from the tested formulations is in accordance with kinetics of "I" order. Conclusions. Formulations produced on carbopol base are characterised by high pharmaceutical availability of ketoprofen and therapeutic agents contained in dry standardized plant extracts from Harpagophytum Procumbens and Solidago Virgaurea L. The suggested formulations can be an alternative for market preparations of analgesic, anti-inflammatory and antioedematous activity. Key words: anti-inflammatory hydrogels, ketoprofen, plant extracts, pharmaceutical availability |