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Copyright @ Pol J Cosmetol
Pol J Cosmetol 2007, 10(4): 280-290pl,en  Application of chitosan in the prescription of anti-inflammatory hydrogels with ketoprofenMagdalena Piechota-Urbańska, Grażyna Samczewska, Justyna Kołodziejska Katedra Farmacji Stosowanej, Uniwersytet Medyczny w Łodzi Summary Introduction. An attempt was made to use chitosan as polycation to obtain stable gels with ketoprofen designed for skin. Aim. To aim of the study was to test physicochemical properties of the produced gels and formulations and to estimate ketoprofen pharmaceutical availability. Material and method. Variant hydrogen vehicles and preparations were obtained in water by adding lactic acid solution to a suspension of chitosan from shrimp shells (SD=90%) and other components. Extensometric method was used to test spreadness of the preparations, gravimetric method to determine the rate of volatile component loss, while viscosity parameters were determined with cone-plate digital rheometer. Potentiometric method was applied to measure pH of the produced hydrogels. The test for ketoprofen pharmaceutical availability was performed with spectrophotometric method. Results. All the suggested systems have pH compatible with skin pH. The results of the measurement of water loss point to comparable increase of structural viscosity of all the tested preparations and thus, to similar changes of ketoprofen pharmaceutical availability during application of the hydrogel. Viscosity tests demonstrated that the produced vehicles and preparations with ketoprofen are viscoeleastic systems having yield stress. The flow curves are nearly straight lines (Bingham fluid). Introduction of propylene glycol and glycerol into hydrogel prescription contributes to the decrease of spreadness, viscosity and pharmaceutical availability of ketoprofen. The most beneficial application properties were obtained for the formulation in which the ratio of chitosan to lactic acid is 2:4 (formulation F2). Conclusion. All the produced formulations are characterised by high pharmaceutical availability of ketoprofen. Key words: anti-inflammatory hydrogels, chitosan, ketoprofen, pharmaceutical availability |