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Pol J Cosmetol 2007, 10(1): 56-64pl,en  Dental anti-inflammatory hydrogels with ketoprophene, brine and zinc chloride. Part. I. Rheological studies and pharmaceutical availability under in vitro conditionsJustyna Kołodziejska Katedra Farmacji Stosowanej, Uniwersytet Medyczny w Łodzi Summary Objective. The study was aimed at the development of a compatible dental hydrogel containing medicinal agents exhibiting anti-inflammatory effects (ketoprophen, medicinal brine, zinc chlorine). An attempt was made to estimate the effects of hydrogel vehicle and zinc chloride on the pharmaceutical availability of hydrotropic adduct of ketoprophene. Material and method. Recipes of hydrogels with ketoprophene, brine and zinc chloride on variant vehicles (vegetable rubber, derivatives of cellulose, Carbopoles) were worked out. Rheological studies of the preparations were carried out: the stretchability test was carried out using extensiometer, whereas viscosity parameters were tested using the cone - plate rheometer. The potentiometric method was used for pH measurement. The study of pharmaceutical availability of ketoprophene was carried out using the membrane method. The amount of the medicinal agent diffusing from hydrogel to acceptor fluid was determined by spectrophotometric method. Results. The release of ketoprophene is most effective from hydrogels with Carbopoles. Surface areas under release curves, obtained for these formulations, are in the range: 152,12-206,52 a.u (agreed units)., whereas for the other model preparations the values not higher than 36,35 a.u were obtained. Introducing the zinc chloride causes an improvement in rheological preparations (structural viscosity, flow limit, stretchability) of all formed preparations. Model hydrogels with the vehicle based on hydroxyethylcellulose exhibit optimum rheological properties which do not change significantly during exposure at the human body temperature. Conclusions. The studies indicated that from the application point of view the best vehicle for hydrogels with ketoprophene, brine and zinc chloride is the system based on Carbopoles. The pH (aH+) value of model preparations with Carbopoles, approximating pKa ketoprophene (5,94), determines a very high pharmaceutical availability of hydrotropic adduct of the medicinal agent. Addition of zinc chloride induces a decrease in the medicinal agent release from hydrogels with Carbopols. Key words: inflammatory conditions, oral cavity, ketoprophen, medicinal salts, zinc chloride, rheological properties, pharmaceutical availability |