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Copyright @ Pol J Cosmetol
Pol J Cosmetol 2006, 9(4): 212-221pl,en  New look at gold complexes as potential antitumor drugsElżbieta Budzisz Zakład Chemii Surowców Kosmetycznych, Katedra Kosmetologii, Wydział Farmaceutyczny, Uniwersytet Medyczny w Łodzi Summary Metal ions drugs are known to bind with nucleic acids and thereby alter their conformation and biological function. The interaction of these complexes with DNA depends on the nature of both metal and ligands: a certain site of coordination is preferred. Gold (I) and Gold (III) complexes overcome some of these challenges by forming strong covalent attachments to their targets. Generally the gold complexes exhibit interesting cytotoxic and antitumor properties, but until now their development has been heavily hampered by their poor stability under physiological conditions. Au (III) is isoelectronic with Pt (II)-d8 system and usually forms square planar complexes in solution. Herein, I present a new look at gold(I) and gold(III) complexes, taking into account that various studies have shown their great attractiveness in respect of their application as anticancer agents. Key words: gold (I)/(III) complexes, antitumor activity |