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Copyright @ Pol J Cosmetol
Pol J Cosmetol 2006, 9(2): 122-134pl,en  Structural viscosity of pharmaceutical hydrogel products and the rate of ketoprofen release through artificial and natural phase boundaryMarian M. Zgoda, Justyna Kołodziejska, Michał J. Nachajski Zakład Technologii Postaci Leku, Katedra Farmacji Stosowanej Uniwersytetu Medycznego w Łodzi Summary Introduction. Rheological parameters of hydrogels with nonsteroidal anti-inflammatory drugs depend on the preparations prescription. The aim of the study was to establish the relation between rheological properties of market preparations with ketoprofen (structural viscosity, kinetics of volatile components loss) and pharmaceutical availability of therapeutic agent. Material and methods. Rheological parameters of hydrogel products with ketoprofen designed for skin were tested. The rate of volatile components loss was estimated with gravimetric method, while viscosity parameters of the preparations were determined with cone-plate digital rheometer. Testing of the kinetics of the therapeutic agent (ketoprofen) release from hydrogels through a standard membrane of Viscing type and through natural membranes to external compartment was carried out in vitro. Results and discussion. The process of volatile components loss is the most effective from products which contain ethanol in their prescription composition. Loss of volatile components causes the increase of structural viscosity and decrease of the rate of ketoprofen diffusion. The process of ketoprofen diffusion from the tested hydrogel preparations proceeds in accordance with kinetics of "O" order. The effectiveness of release, independently of the applied membrane (Viscing, pig dermis) is the highest from the preparation containing ketoprofen adduct with lysine. Conclusions. The study on pharmaceutical availability in vitro confirms, calculated on the basis of viscosity measurements, theoretical values of therapeutic agent diffusion coefficients and the assessment of hydrogel structure stability anticipated on the basis of the process of volatile components loss. Key words: ketoprofen, Febrofen, Ketoprom, Profenid, volatile components, viscosity, dialysis membranes, pharmaceutical availability |