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Copyright @ Pol J Cosmetol
Pol J Cosmetol 2006, 9(2): 118-121pl,en  Application of QSAR analysis in cosmetology. Part IIDorota Kusztal, Piotr Włodno Zakład Chemii Analitycznej Katedra Chemii Medycznej Uniwersytetu Medycznego w Łodzi Summary Aims of the thesis. In the second part of research we analyzed a correlation between the values of parameters such as polarizability, refraction and logP values calculated experimentally. Material and methods. Our research comprised calculation of polarizability and molar refraction by means of HyperChem 7.0 manufactured by Hypercube. 48 compounds with the comparatively simple structure were examined. Results. Defined correlations and conducted calculation allow us to draw a conclusion that the examined physicochemical parameters can be a descriptor of lipophilicity. Conclusion. Reduction of assessment time of descriptors cause that polarizibility and molar refraction can be taken into account in the tentative assessment of chemical compound. Key words: lipophilicity, logP, QSAR |