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Copyright @ Pol J Cosmetol
Pol J Cosmetol 2022, 25(2): 103-107pl  Parabens bioavilability from hydrogelsMagdalena Krulikowska 1/, Jacek Arct 2/, Patrycja Górska 3/ 1/ Action Poland Sp.z o.o. 2/ Fundacja dr Seidla w Warszawie 3/ Wyższa Szkoła Zawodowa Kosmetyki i Pielęgnacji Zdrowia w Warszawie Summary Introduction. Parabens are one of the most popular and commonly used preservatives. The safety of their use in cosmetics largely depends on the ability to penetrate the skin. Transepidermal transport is a complicated process. The most important factors influencing the penetration of substances into the skin include properties of the active substance, the physicochemical form of the product, and the presence of transepidermal transport promoters. Aim. The aim of the study was to evaluate the permeation rate of selected four parabens through model membranes from a ready-made cosmetic form - hydrogel. Materials and methods. The permeation rates of selected parabens through the lipid membrane and the porcine skin membrane were investigated. The experiments were carried out using Franz diffusion cells, and a hydrogel containing 0.04% paraben was used as the donor system. Results and conclusions. The correlation between the coefficients of penetration through the lipid membrane and pig skin reaches the value of R=0.99. A linear decrease in the permeability of parabens together was observed with an increase in their lipophilicity. The research results show a significant influence of the cosmetic form on penetration. This is confirmed by the measurement of the permeation rate from a lower viscosity formulation. The results indicate the need to assess the bioavailability of parabens from finished products. Key words: parabens, permeation, in vitro, membranes, Franz chambers |